发明名称 |
Structurally modified peptides that are resistant to peptidase degradation. |
摘要 |
Human melanoma cells bear antigens that are recognized by autologous CD8<+ >cytotoxic T-lymphocytes. The invention involves the reception of particular peptides analogues of the MZ2-E antigen by HLA molecules. Disclosed herein are peptide analogues of the tumor antigen MZ2-E that have been modified to resist peptidase degradation, and which bind HLA molecules to form a complex whose recognition by specific cytolytic T cells leads to lysis of the complex. The identification by cytolytic T cells of the peptide analogue/HLA complex may be used in diagnostics, or therapeutically. |
申请公布号 |
ZA9711158(B) |
申请公布日期 |
1998.06.15 |
申请号 |
ZA19970011158 |
申请日期 |
1997.12.11 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
BENOIT VAN DEN EYNDE;JEAN EDOUARD GAIRIN;MAHA AYYOUB;HONRE MAZARGUIL;BERNARD MONSARRAT |
分类号 |
A61K38/00;A61K39/00;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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