摘要 |
2-(pyrimidin-4-yloxy)methyl)phenylacetic acid derivatives of formula (I) and their salts and N-oxides are new. R1 = H or 1-4C alkyl; R2 = halo, CH3, CH2CH3, halomethyl or haloethyl; R3 = phenyl, phenoxy, phenoxymethyl, benzyloxy or heteroaryl, (all optionally ring-substituted), H, amino, OH, SH, halo, 1-8C alkyl (optionally substituted by Ar or halo), alkoxy-(1-4C alkyl), alkoxy, mono- or di- alkylamino, alkylthio, alkylsulphoxy, alkylsulphonyl, 3-8C cycloalkyl, trialkylsilyloxy; Ar = phenyl (optionally mono- or di-substituted by halo, CN, NO2, 1-4C alkyl, 1-4C haloalkyl or 1-4C alkoxy); R4 = H, CN, halo, 1-4C alkyl, 1-4C haloalkyl or 1-4C alkoxy; Q = C(=NOCH3)CONHCH3, C(=NOCH3)COOCH3 or N(OCH3)COOCH3; alkyl, alkoxy have 1-8 C unless specified otherwise. |