NUKLEINSÄURE FRAGMENT DES X-CHROMOSOMEN BEREICHS BETEILIGT AM EMPFINDLICHEN X-SYNDROM, NUKLEOTIDISCHE SONDE UND VERFAHREN FÜR DIE DIAGNOSE VON GEISTIGER ZURÜCKGEBLIEBENHEIT MIT EMPFINDLICHEM X

摘要

A new nucleic acid fragment (I). of at least 156p or nucleotides, is derived from the Xq27-q28 region of the X chromosome. It is contained within the approx. 225 kb DNA segment defined between probes St677 and Do33. Also new are (1) DNA or RNA fragments (Ia) which hybridise selectively with (I); (2) cDNA (Ib) corresponding to (I); (3) probes (II) which hybridise selectively with any of (I),(Ia) and (Ib); (4) fragments of mRNA able to hybridise to (II); (5) recombinant DNA (Ic) contg. at least one fragment (I),(Ia) or (Ib) plus transcription/translation control elements; (6) cloning and expression vectors contg. (Ic); (7) host cell, transformed with these vectors; (8) proteins (III) produced from (Ic) and (9) antibodies (Ab) raised against (III). More specifically (I) is adjacent to, or contains, CpG sites in the region of 20 kb around the 125 kb position as defined on a genetic map.