STEROID ESTERS, METHOD FOR THE MANUFACTURE THEREOF AND THEIR PHARMACEUTICAL USE

摘要

Disclosed are novel steroid esters of formula (I), wherein m means 1 or 2, n is 0 or 1, X is F or CN and the line drawn between carbon atoms 15 and 16 symbolizes the possible presence of a dual bond, excluding compound (Z)-6'-(4-cyanphenyl)-9,11 alpha -dihydro-17 beta -hydroxy-17 alpha -[3-(1-oxo-2-methylpropoxy)-1-propenyl]-4'H-naphto[3',2',1';10,9,11] ester-4-en-3-on. Derivatization occurs with a carboxylic acid. The novel compounds are characterized by a significantly enhanced solubility in comparison with the basic hydroxy compounds, and by enhanced biological effectiveness and selectivity. Said novel compounds are suitable for the production of medicaments.