A cell-culture system comprising a vessel and a wound dressing system is disclosed wherein the cell culturing substrate material of the wound dressing system is releasably secured by e.g. peelable adhesive or heat sealing means, to a part of the interior surface of the vessel. The culturing substrate may optionally comprise a detachable handle portion and/or a support layer. In various embodiments, the vessel is formed into two interlocking or mutually fitting parts for example a base and lid, one of which may be peelably attached to the other. The system may also comprise a support which supports the dressing system and resiliently engages the vessel.