| 摘要 |
<p>A method for reducing the rejection of allografts comprising donor tissue containing antigen presenting cells (APC's), which method comprises: exposing said donor tissue modified by treating said donor tissue with a photosensitizing agent to light having a wavelength absorbed by said photosensitizing agent for a time sufficient to diminish immunogenicity by functionally attenuating the APC's in the donor tissue under conditions wherein said light is not cytotoxic. By subjecting donor tissue to photodynamic therapy, the mean survival time of grafts, particularly skin allografts, was significantly lengthened. The photosensitizer may also be part of a conjugate containing a target-specific moiety.</p> |
