| 摘要 |
<p>A process to synthesize the dihydrofolate reductase inhibitor, 4-amino-4-deoxy-10-deazaaminopterin (MDAM). The process synthesizes the key intermediate, pteroic acid in 5 steps, and uses commonly available starting materials. The steps include the formation of a 6-substituted pteridine, followed by alkylation, hydrogenation, and hydrolysis steps to form pteroic acid from the starting material which is tetraamino pyrimidine, or a salt thereof.</p> |
