ANTISENSE INHIBITION OF HUMAN ADHESION MOLECULES

摘要

The present invention provides a method for the treatment of human conditions and diseases that have an inflammatory component, including but not limited to acne, psoriasis, arthritis, transplanted organ rejection, wounds, burns, septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I, human E-selectin, or human VCAM-1 mRNA transcripts using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I, human E-selectin, or human VCAM-1 mRNAs is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I, human E-selectin, or human VCAM-1 mRNAs and compositions comprising the aforementioned oligonucleotides.