IMPROVEMENTS IN OR RELATING TO NAPHTHYL ACETALDEHYDES AND DERIVATIVES THEREOF

摘要

1,274,743. Antiinflammatory &c. medicines. SYNTEX CORP. 16 May, 1969 [2 July, 1968], No. 25081/69. Heading A5B. Pharmaceutical-compositions in conventional forms for oral administration and having antiinflammatory, analegsic, antipyretic and antipruritic activity comprise a #-naphtylacetaldehyde derivative of one of the formulµ wherein R1 and R2 are alkoxy; or R1 and R2 taken together are -O, ethylenedioxy or 1', 2'-propylenedioxy; one of R3 and R4 is hydrogen, the other is hydrogen, methyl, ethyl or difluoromethyl; or R3 and R4 taken together are methylene, halomethylene or difluoromethylene; R5 (at position C-1,4,5,7 or 8) is alkyl, hydrogen, trifluoromethyl, fluoro, chloro, hydroxy, a hydrolyzable ester, oxyether or thioether; R6 is alkyl, cycloalkyl, hydroxymethyl, alkoxymethyl, trifluoromethyl, vinyl, ethynyl, fluoro, chloro, hydroxy, a hydrolyzable ester, oxyether, thioether, formyl, acetyl or aryl and each of R7 and R8 (at position C-1,4,5, 7 or 8) is alkyl, fluoro, chloro, trifluoromethyl, hydroxy, a hydrolyzable ester, oxyether or thioether, provided that when one of R7 and R8 is hydroxy, oxyether or thioether, the other is the identical group or alkyl, fluoro, chloro or a hydrolyzable ester and a pharmaceutical excipient. Excluded are known solutions and mixtures resulting directly from the preparation of any of the known compounds of the above formulµ. (Compounds of of the above formulµ which are novel are disclosed in Specification 1,274,744; see Division C2).