| 摘要 |
The present invention relates to a neuron and neural tumor growth regulatory system, based on the novel protein, arretin and its isoforms and fragments thereof, its receptor, antibodies directed against the components of this system and diagnostic, therapeutic, and research uses for each of these aspects. This protein has an apparent molecular weight of approximately 70 kDa. Embodiments of the invention comprise the amino acid sequence and probes designed therefrom for nucleic acid sequences encoding arretin. Alternatively, tagged arretin protein for use as a reporter to detect receptors of arretin, which are then sequenced and used to obtain probes for the nucleic acid sequences encoding arretin receptors, are included. The present invenetion further relates to arretin receptors and fragments thereof as well as the nucleic acid sequences coding for such arretin receptors and fragments, and their therapeutic and diagnostic uses. Substances which function as either aganists or antagonists to arretin receptors are also envisioned and included within the scope of the present invention. |
