| 发明名称 |
LYSOSOMAL PROTEINS PRODUCED IN THE MILK OF TRANSGENIC ANIMALS |
| 摘要 |
<p>The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.</p> |
| 申请公布号 |
EP0845939(A2) |
申请公布日期 |
1998.06.10 |
| 申请号 |
EP19960928405 |
申请日期 |
1996.07.31 |
| 申请人 |
PHARMING B.V. |
发明人 |
REUSER, ARNOLD, J., J.;VAN DER PLOEG, ANS, T.;PIEPER, FRANK, R.;VERBEET, MARTIN, PH. |
| 分类号 |
A01K67/027;A23C9/20;A23C23/00;A61K31/00;A61K35/20;A61K38/00;A61K38/43;A61K38/46;A61K38/47;A61P43/00;C12N9/24;C12N9/26;C12N15/12;C12N15/85;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
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