Naphthalene derivatives as prostaglandin I2 agonsists

摘要

PCT No. PCT/JP95/00373 Sec. 371 Date Oct. 10, 1996 Sec. 102(e) Date Oct. 10, 1996 PCT Filed Mar. 8, 1995 PCT Pub. No. WO95/24393 PCT Pub. Date Sep. 14, 1995A compound of the formula <IMAGE> wherein R1 is carboxy or protected carboxy, R2 is hydrogen, hydroxy or protected hydroxy, R3 is hydrogen, hydroxy, protected hydroxy, etc., R4 is hydrogen or halogen, A1 is lower alkylene, A2 is bond or lower alkylene, -R5 is <IMAGE> (in which R6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and <IMAGE> and a pharmaceutically acceptable salt thereof which are useful as medicaments.