发明名称 |
Methods of preparing tissue plasiminogen activator derivative composition |
摘要 |
Tissue plasminogen activator (t-PA) derivatives are produced in useful quantities using recombinant DNA techniques. Specific derivatives include amino acid deletion derivatives and amino acid substitution derivatives. A deletion derivative lacking the N-terminal first 68 amino acids is specifically exemplified having requisite t-PA characteristics. The invention disclosed thus enables the production of t-PA derivatives via recombinant means. Methods, expression vehicles and various host cells useful in the production of said t-PA derivatives are also disclosed.
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申请公布号 |
US5763253(A) |
申请公布日期 |
1998.06.09 |
申请号 |
US19950474160 |
申请日期 |
1995.06.06 |
申请人 |
GENENTECH, INC. |
发明人 |
GOEDDEL, DAVID V.;KOHR, WILLIAM J.;PENNICA, DIANE;VEHAR, GORDON A. |
分类号 |
C12N15/09;A61K;A61K35/12;A61K35/74;A61K38/00;A61K38/46;C07H21/02;C07H21/04;C07K14/00;C12N;C12N1/00;C12N1/16;C12N1/20;C12N1/21;C12N5/00;C12N5/10;C12N7/00;C12N9/50;C12N9/52;C12N9/64;C12N9/72;C12N15/00;C12N15/12;C12N15/58;C12N15/70;C12N15/85;C12P19/34;C12P21/00;C12R1/125;C12R1/19;C12R1/42;C12R1/43;C12R1/865;C12R1/91;G01N;(IPC1-7):C12N1/21;C12N15/55 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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