发明名称 |
THIAZOLE AND IMIDAZOLE DERIVATIVES AND ANTIULCER COMPOSITION CONTAINING SAME |
摘要 |
A thiazole or imidazole derivative having the general formula (I): (see fig. I) wherein: R1 and R2, which may be the same or different, each independently represent a hydrogen atom, or a phenyl or heteroaryl group, or R1 and R2 may together form a benzene ring which may be optionally substituted by a halogen atom or a lower alkyl optionally substituted by a halogen atom, lower alkoxy or nitro group; A represents a sulfur atom or -NH-; B represents a lower alkoxy group optionally substituted by a halogen atom; a five- or six-membered saturated heterocyclic ring containing one nitrogen or oxygen atom which ring may be optionally substituted; a six-membered saturated heterocyclic ring containing one oxygen atom plus one nitrogen atom; a group -XR3 where X represents a group -NR4 wherein R3 and R4, which may be the same or different, each independently represent a lower alkyl group; or a group -NHC(=Y)R5 where Y represents an oxygen or sulfur atom or a group =NCN or =CHNO2, and R5 represents a group -NHR6 or -SR6 wherein R6 represents a lower alkyl group optionally substituted by a halogen atom; m is an integer from 1 to 4; and n is an integer from 0 to 2; and their pharmacologically acceptable salts. The compounds has an antiulcerative activity.
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申请公布号 |
CA2040011(C) |
申请公布日期 |
1998.06.09 |
申请号 |
CA19912040011 |
申请日期 |
1991.04.08 |
申请人 |
MEIJI SEIKA KABUSHIKI KAISHA |
发明人 |
MACHINAMI, TOMOYA;YASUFUKU, KAZUE;SHIBAHARA, SEIJI;YUDA, YASUKATSU;HIRANO, FUMIYA |
分类号 |
A61K31/415;A61K31/4184;A61K31/425;A61K31/426;A61K31/428;A61K31/443;A61K31/445;A61K31/454;A61K31/535;A61K31/5355;A61P1/04;C07D233/84;C07D235/28;C07D277/20;C07D277/36;C07D277/56;C07D277/74;C07D277/76;C07D403/12;C07D405/04;C07D405/12;C07D417/04;C07D417/12;(IPC1-7):C07D233/84;C07D401/04;C07D413/04;A61K31/33 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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