| 摘要 |
<p>An agent comprises anti-sense oligos directed to adenosine receptors for allevation of respiratory ailments and inflammation. The agent is provided as a composition, various formulations, and kit. The present agents may be administered in an anti-bronchoconstriction and/or anti-inflammation effective amount to alleviate the bronchoconstriction and inflammation afflicting a subject. Preferred agents contain anti-sense oligonucleotide targeting the adenosine A1, A2a, A2b and/or A3 receptors and bradykinin B2 receptor. The method is useful for treating patients afflicted with asthma and other respiratory problems. Pharmaceutical formulations are also disclosed.</p> |
