CEPHALOSPORIN DERIVATIVES

摘要

Provided are cephem derivatives represented by general formula (I) wherein Q is an optionally substituted pyridinium group connected to the sulfur atom via a ring carbon atom; X is halogen; Y is hydrogen or halogen; L<1> is a furan group, a thiophene group, a C2-C10 alkyl group, or a C2-C10 alkyl group interrupted by one or more groups independently selected from vinyl, S, SO, SO2, SO2NH, (IIa), (IIb); n is 0 or 1; A is CO2H, PO3H2, SO3H or tetrazole; and R<1> is hydrogen or a carboxyl-protecting group; and pharmaceutically acceptable salts and/or prodrugs thereof. The derivatives are gram-positive antibacterial agents especially useful in the treatment of diseases caused by methicilin-resistant Staphylococcus aureus (MRSA).