ERYTHROMYCIN A DERIVATIVES

摘要

Erythromycin A derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, each having a potent antibacterial activity against not only conventional erythromycin-sensitive bacteria but also erythromycin-resistant bacteria, wherein R1 and R2 represent each group (a), group (b), pyridylacetyl, C4-C8 cycloalkylmethyl, 1,2bis(ethoxycarbonyl)vinyl, etc.; and A represents a group represented by OC(=O)-R17, -OC(=O)-CH2R17, -OC(=O)-NH-R17, -O-R17 or -OC(=O)-O-R17.