| 摘要 |
<p>Described herein are compounds selective for a 5-HT1D-like receptor, which have general formula (I), wherein A is selected from a six-membered, non-aromatic, optionally substituted carbocycle and a six-membered, non-aromatic, optionally substituted heterocycle having one or two heteroatoms selected from O, S, SO, SO2 and NR4; R1 is selected from H and OH; n is 0 or 1 as permitted by chemical structure; R2 is selected from CR5R6CH2NR7R8 or a group of formula (II), (III) or (IV); R3 is selected from H and benzoyl; R4 is selected from H, loweralkyl, benzyl, loweralkylcarbonyl, loweralkylaminocarbonyl; loweralkylaminothiocarbonyl, loweralkanoyl, loweralkylaminoimide and loweralkoxy-substituted loweralkylene; R?5 and R6¿ are independently selected from H, loweralkoxy and hydroxy; R?7 and R8¿ are independently selected from H and loweralkyl or R?7 and R8¿ form an alkylene bridge which, together with the nitrogen atom to which they are attached, creates an optionally substituted 3- to 6-membered ring; ----- denotes a single or double bond; and R?9, R10 and R11¿ are independently selected from H and loweralkyl. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT¿1D?-like receptor is implicated, such as migraine.</p> |
