发明名称 |
CHEMICALLY MODIFIED ENZYMES |
摘要 |
Modified enzymes are provided in which at least one amino acid, such as asparagine, leucine, methionine or serine, of an enzyme is replaced with a cysteine and the thiol hydrogen is replaced with a substituent group providing a thiol side chain selected from the group consisting of: a) -SR1R2, wherein R1 is an alkyl and R2 is a charged or polar moiety; b) -SR3, wherein R3 is a substituted or unsubstituted phenyl; c) -SR4, wherein R4 is substituted or unsubstituted cyclohexyl; d) -SR5, wherein R5 is C10-C15 alkyl; and e) -SR6 wherein R6 is a C1-6 alkyl. Also, methods of producing the modified enzymes are provided, as well as detergent and feed additives and a composition for the treatment of a textile. A method for using the modified enzymes in organic synthesis is additionally provided. Further, modified enzymes having improved activity, altered pH profile and/or wash performance are provided.
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申请公布号 |
CA2273079(A1) |
申请公布日期 |
1998.06.04 |
申请号 |
CA19972273079 |
申请日期 |
1997.11.24 |
申请人 |
GENENCOR INTERNATIONAL, INC.;JONES, J. BRYAN |
发明人 |
JONES, J. BRYAN;DESANTIS, GRACE;BOTT, RICHARD R.;GRAYCAR, THOMAS P.;MITCHINSON, COLIN |
分类号 |
C11D3/386;C12N9/00;C12N9/54;C12S3/00;D06M16/00;(IPC1-7):C12N9/00 |
主分类号 |
C11D3/386 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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