| 摘要 |
<p>Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal β-aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the β-aminoalcohol Z is -NR-CH(Q)-CH2OH, Q is (CH2)n-NH-A, n is 1-6 and A is H or -C(=NH)NH2, and R is CH3 or C2H5, and the moiety S wherein X is a D-aromatic α-aminoacid and Y is an aliphatic α-aminoacid, and have oxytocin antagonist activity. Also disclosed is: a method of their synthesis; pharmaceutical compositions containing these analogues; the synthesis of such compositions; a method of control of uterine contractions.</p> |
