| 发明名称 |
2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole |
| 摘要 |
A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (S,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed. |
| 申请公布号 |
AU5432698(A) |
申请公布日期 |
1998.06.03 |
| 申请号 |
AU19980054326 |
申请日期 |
1997.11.12 |
| 申请人 |
SEPRACOR, INC. |
发明人 |
PATRICK KOCH;JOHN R. MCCULLOUGH;CHRIS H SENANAYAKE;GERALD J. TANOURY;YAPING HONG |
| 分类号 |
C07D405/14;A61K31/496;A61P31/10;C07D249/12;C07D405/06;C07D521/00 |
主分类号 |
C07D405/14 |
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