| 摘要 |
A novel H-phosphonate oligonucleotide derivative. A process for synthesizing the derivative which comprises synthesizing by the solid-phase method an oligomer having an alkoxyphosphonic acid having an alkylene group with a moderate chain length at each of the 3' and 5' ends, in order to synthesize H-phosphonate oligonucleotide in a high yield while preventing decomposition thereof under basic conditions during synthesis. The derivative is apt to form a double strand together with the target gene, has resistance to phosphodiesterases, and is incorporated into cells efficiently. The derivative is expected to be utilized especially as an antisense. |
