| 摘要 |
Mixed esters of antiviral nucleosides such as compounds of Formula (I), where B is natural or unnatural nucleotide base, X is O or CH2, Y and Z are each H, or together form a bond, or Y is methylene or -CH(OH)- and Z is a bond thereto; n is 0 or 1; one of R1 and R2 is the acyl residue of an aliphatic amino acid and the other is -C(=O)C5-C21 saturated or monounsaturated alkyl; and pharmaceutically acceptable salts thereof have advantageous pharmacokinetic and other properties. |
