Process for the production of the dexfenfluramine hydrochloride.

摘要

Process for the production of the anorexic drug dexfenfluramine hydrochloride (INN) which comprises the ethylation of the (S),(S)-N-(1-phenylethyl)- alpha -methyl-3-(trifluoromethyl)benzeneethanamine or of a salt thereof with an organic or inorganic acid, the debenzylation of the resulting intermediate (S),(S)-N-ethyl-N-(1-phenylethyl)- alpha -methyl-3-(trifluoromethyl)benzeneethanamine or of a salt thereof with an organic or inorganic salt by catalytic hydrogenation and, optionally, the salification with hydrochloric acid.