Antibiotic formulation and use for drug resistant infections

摘要

PCT No. PCT/US93/04501 Sec. 371 Date Jun. 23, 1993 Sec. 102(e) Date Jun. 23, 1993 PCT Filed May 11, 1993A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.