发明名称 |
Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
摘要 |
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure <IMAGE> I or <IMAGE> IA or <IMAGE> IB including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) -O-; or (3) <IMAGE> B is: <IMAGE> or <IMAGE> or <IMAGE> or <IMAGE> or <IMAGE> or <IMAGE> or <IMAGE> and wherein L2, L1, R1, R2, R3, R3', R3a, R3b, R4, R4', R5, X, <IMAGE> are as defined herein.
|
申请公布号 |
US5760246(A) |
申请公布日期 |
1998.06.02 |
申请号 |
US19960767923 |
申请日期 |
1996.12.17 |
申请人 |
BILLER, SCOTT A.;DICKSON, JOHN K.;LAWRENCE, R. MICHAEL;MAGNIN, DAVID R.;POSS, MICHAEL A.;ROBL, JEFFREY A.;SLUSARCHYK, WILLIAM A.;SULSKY, RICHARD B.;TINO, JOSEPH A. |
发明人 |
BILLER, SCOTT A.;DICKSON, JOHN K.;LAWRENCE, R. MICHAEL;MAGNIN, DAVID R.;POSS, MICHAEL A.;ROBL, JEFFREY A.;SLUSARCHYK, WILLIAM A.;SULSKY, RICHARD B.;TINO, JOSEPH A. |
分类号 |
C07C233/58;C07C233/59;C07C233/60;C07C233/62;C07C233/63;C07C233/78;C07C235/40;C07C237/12;C07C237/24;C07C255/41;C07C259/08;C07C271/22;C07C271/24;C07C291/04;C07C307/06;C07C311/21;C07C311/46;C07C317/12;C07C317/44;C07C321/22;C07C323/60;C07D207/32;C07D207/335;C07D213/40;C07D213/64;C07D213/75;C07D221/16;C07D233/88;C07D233/90;C07D233/92;C07D295/185;C07D307/52;C07D311/82;C07D333/20;C07D405/12;C07D407/12;C07D409/12;C07F7/18;C07F9/40;C07F9/576;C07F9/58;C07F9/6506;C07F9/655;C07F9/6571;(IPC1-7):C07D235/16 |
主分类号 |
C07C233/58 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|