发明名称 |
Treatment of CD4 T-cell mediated conditions |
摘要 |
A method for the selective depletion of activated CD4+ T-cells in vivo by using immunotoxins comprising the OX-40 antibody conjugated to a toxic molecule (such as Ricin-A chain). The administration of these specific immunotoxins is used therapeutically to deplete autoimmune reactive CD4+ T-cells which have been implicated in diseases including Multiple Sclerosis, Rheumatoid Arthritis, Sarcoidosis, and Autoimmune Uveitis. This type of therapy is also beneficial for eradicating CD4+ T-cell lymphomas and alloreactive CD4+ T-cells involved with a transplantation reaction. The use of the human form of the OX-40 antibody will also help in the early diagnosis of all the diseases mentioned above.
|
申请公布号 |
US5759546(A) |
申请公布日期 |
1998.06.02 |
申请号 |
US19940192480 |
申请日期 |
1994.02.04 |
申请人 |
WEINBERG, ANDREW D.;VANDENBARK, ARTHUR A. |
发明人 |
WEINBERG, ANDREW D.;VANDENBARK, ARTHUR A. |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61K47/48;A61K49/00;A61K51/00;A61K51/10;A61P29/00;A61P35/02;A61P37/00;A61P37/06;C07H21/04;C07K14/705;C07K14/725;C07K14/73;C07K16/28;C12N15/09;C12P21/02;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):C07K16/28;C07K19/00 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|