| 摘要 |
PROBLEM TO BE SOLVED: To obtain an oral preparation useful for chronic cardiac insufficiency, excellent in shelf stability of a forskolin derivative salt, by using both the forskolin derivative and a specific alkali metal compound. SOLUTION: This oral preparation comprises a forskolin derivative salt and a halogenated alkali metal as medicinal components. A compound of the formula [R<1> is H; R<4> is vinyl, ethyl or cyclopropyl; one of R<2> and R<3> is CO (CH2 )m NR<5> R<6> (R<5> and R<6> are each H, an alkyl or R<5> and R<6> are bonded to form an alkylene; (m) is 1-5) and the other is H or CO(CH2 )n X [X is NR<7> R<8> (R<7> and R<8> are each H, an alkyl, etc.); (n) is 1-5]] is preferable as the forskolin salt. Sodium chloride or potassium chloride is preferable as the halogenated alkali metal. The amount of the halogenated alkali metal is preferably 0.01-26 pts.wt. based on 1 pt.wt. of the forskolin derivative. |
