| 摘要 |
<p>A compounds of the following formula: (see formula) and its pharmaceutically acceptable sal thereof, wherein R1 and R2 are independently hydrogen, C1-4 alkyl, C3-7 cicloalyl, C2-4 alkenyl, C1-4 alkoxy, C1-4 alkoxy, C1-4 alkylthio, phenyl or phenyl -C1-4 alkyl; or R1 and R2 are taken together with the nitrogen to which they are attached and form optionally substituted, saturated or unsaturated 3-, 4-, 5-, -6- or 7- membered heterocyclic containing one to two heteroatoms, provided that the heterocyclic is not pyrrolidinyl; R3 is hydrogen, C1-4 alkyl or a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alcoxy alkyloxy, CF3 and carboxy-C1-4 alkyloxy; and X is phenyl, naphthyl, byphenyl, indanyl, bezofuranyl, benzothuophenyl, 1-tetralone-6yl, C1-4 alkylenedioxy, pyrydyl, furyl or thienyl, these groups being optionally substitued with up to three substituents selected from halo, C1-4 alkyl, C1-4 alkoxy, hydroxy, NO2, CF3, and SO2CH3.</p> |
