发明名称 |
USE OF MUTEINS OF WILD-TYPE CYTOKINES AS IMMUNOGENS. |
摘要 |
<p>These are pharmaceutical compounds used to treat or prevent diseases caused by the over-production of a specific wild-type cytokine, characterised by the fact that they contain as an active principle at least one mutant of that wild-type cytokine. In its widest scope the invention consists in the use of muteins of a specific wild-type cytokine, that are also receptor antagonists of the latter, as immunogens to elicit antibodies directed against this wild-type cytokine and capable of neutralising it in those diesases caused by its excessive production. Figure 4 shows that antibodies developed in NSE/hIL-6 transgenic mice immunised with a human interleukin 6 mutein are capable of recognising wild-type interleukin 6 and of neutralising its biological activity.</p> |
申请公布号 |
MX9801550(A) |
申请公布日期 |
1998.05.31 |
申请号 |
MX19980001550 |
申请日期 |
1996.08.22 |
申请人 |
INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE;P. ANGELETTI SPA. |
发明人 |
GENNARO CILIBERTO;ROCCO SAVINO;RICCARDO CORTESE |
分类号 |
C12N15/00;A61K38/19;A61K39/00;A61P37/04;A61P43/00;C12N15/01;(IPC1-7):A61K39/00 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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