发明名称 N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONSCOMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE A ND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
摘要 Disclosed are compounds which inhibit .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits .beta.-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
申请公布号 CA2267065(A1) 申请公布日期 1998.05.28
申请号 CA19972267065 申请日期 1997.11.20
申请人 ELI LILLY & COMPANY;ELAN PHARMACEUTICALS, INC. 发明人 WU, JING;MABRY, THOMAS E.;LATIMER, LEE H.;JOHN, VARGHESE;AUDIA, JAMES E.;FANG, LAWRENCE Y.;THORSETT, EUGENE D.;NISSEN, JEFFREY S.
分类号 A61K31/222;A61K31/223;A61K31/341;A61K31/36;A61K31/381;A61K31/421;A61K31/427;A61K31/433;A61K31/4409;A61P25/28;C07C233/37;C07C233/39;C07C233/46;C07C233/47;C07C233/51;C07C235/34;C07C323/59;C07C323/60;C07C323/62;C07C327/22;C07D213/56;C07D213/81;C07D261/08;C07D263/32;C07D263/56;C07D263/57;C07D271/06;C07D277/62;C07D277/64;C07D285/08;C07D307/46;C07D307/54;C07D307/79;C07D317/60;C07D333/16;C07D333/24;C07D333/28;C07D333/34;C07D333/60;C07K14/47;(IPC1-7):C07C233/51;A61K31/16;C07C333/24;A61K31/33;C07D263/54 主分类号 A61K31/222
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