发明名称 |
LOCAL USE OF IL-1RA IN CORNEAL TRANSPLANT REJECTION OR DISORDERS OF THE EYE |
摘要 |
Topical application of interleukin-1 receptor antagonist (IL-1ra) is shown to promote corneal transplant survival in a murine model of orthotopic allotransplantation, having a significant effect in prolonging graft survival in both high-risk and normal (low-risk) stromal beds. Furthermore, the promotion of graft survival is associated with a significant decrease in corneal inflammation. Therefore, IL-1ra and related antagonists to interleukin1 can be used in a therapeutic composition for topical prophylaxis and treatment of allograft rejection and for local treatment of a wide array of immunogenic inflammatory diseases of the eye. The composition comprises a therapeutically effective amount of IL-1ra in association with a pharmaceutically acceptable carrier vehicle for topical application.
|
申请公布号 |
CA2272073(A1) |
申请公布日期 |
1998.05.28 |
申请号 |
CA19972272073 |
申请日期 |
1997.11.19 |
申请人 |
THE SCHEPENS EYE RESEARCH INSTITUTE, INC. |
发明人 |
DANA, M. REZA |
分类号 |
A61K38/00;A61K38/20;A61P27/02;A61P37/06;A61P43/00;(IPC1-7):A61K38/20 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|