发明名称 |
RECOMBINANT BICISTRON ADENOVIRUS FOR TREATING PATHOLOGICAL CONDITIONS LINKED WITH DYSLIPOPROTEINEMIA |
摘要 |
The invention concerns a defective recombinant virus and preferably an adenovirus characterised in that it comprises at least two nucleic acids coding for distinct enzymes, proteins and/or co-factors involved in the reverse transfer of cholesterol, said nucleic acids being operationally bound to a transcriptional promoter and mutually separated by a sequence coding for an internal entry site of the IRES ribosome. The invention further concerns plasmid constructs useful for preparing these adenovirus, and cells transformed by these plasmids or adenovirus and pharmaceutical compositions containing said adenovirus.
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申请公布号 |
WO9822606(A1) |
申请公布日期 |
1998.05.28 |
申请号 |
WO1997FR02043 |
申请日期 |
1997.11.13 |
申请人 |
RHONE-POULENC RORER S.A.;BENOIT, PATRICK;DUVERGER, NICOLAS;ROUY, DIDIER;SEGURET, SANDRINE |
发明人 |
BENOIT, PATRICK;DUVERGER, NICOLAS;ROUY, DIDIER;SEGURET, SANDRINE |
分类号 |
C12N15/09;A61K48/00;A61P7/00;A61P9/10;C07K14/435;C07K14/47;C12N1/21;C12N7/00;C12N7/01;C12N9/10;C12N9/20;C12N15/62;C12N15/86;C12N15/861;(IPC1-7):C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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