METHODS AND COMPOSITIONS FOR INDUCING ORAL TOLERANCE IN MAMMALS

摘要

The present invention relates to methods and pharmaceutical formulations for orally delivering an antigen to induce tolerance. The antigen is combined with derivatized amino acids or salts thereof. The induction of oral tolerance may be applied clinically for the prevention or treatment of auto-immune diseases and clinical allergic hypersensitivities, and for the prevention of allograft rejection. The figure illustrates examples of the derivatized amino acids.