This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this complex favors regioselective alkylation and increased yields. Copper complexes of the glycopeptide antibiotic starting materials and of the alkylated products are also part of the invention.
申请公布号
WO9822121(A1)
申请公布日期
1998.05.28
申请号
WO1997US21238
申请日期
1997.11.20
申请人
ELI LILLY AND COMPANY;BERGLUND, RICHARD, A.;LOCKWOOD, NANCY, A.;MAGADANZ, HOWARD, E.;ZHENG, HUA