发明名称 NEW PHOSPHONATES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS
摘要 Compounds have the formula (I), in which R1, R2 are the same or different and represent a hydrogen atom, an alkyl group, a cycloalkyl group, an hydroxyalkyl group, an alkenyl group, an alkinyl group or an aralkyl group or R1 and R2 form together an alkylene radical which forms with the bonded oxygen atoms and the phosphorus atom that carries the oxygen atoms a saturated 5- to 8-membered ring; R3 is an optionally substituted amino group, an alkyl group, a cycloalkyl radical or an optionally substituted aryl radical; n is an integer between 1 and 4. Also disclosed are hydrates, solvates and physiologically tolerable salts of these compounds, their optically active forms, processes for preparing the same and medicaments with factor Xa-inhibiting properties containing these compounds.
申请公布号 CA2271814(A1) 申请公布日期 1998.05.28
申请号 CA19972271814 申请日期 1997.11.14
申请人 ROCHE DIAGNOSTICS GMBH 发明人 LEINERT, HERBERT;KUCZNIERZ, RALF;VON DER SAAL, WOLFGANG;KEHR, CHRISTIANE;NEIDLEIN, RICHARD
分类号 A61K31/662;A61K31/675;A61P7/02;A61P9/10;C07F9/553;C07F9/572;C07F9/59;(IPC1-7):C07F9/59 主分类号 A61K31/662
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