| 摘要 |
Oligonucleotide-dendrimer conjugates, wherein dendrimer is the monovalent residue of a dendrimer of the first to tenth generation and oligonucleotide is a natural, modified or synthetic sequence which is composed of natural, modified or synthetic deoxynucleosides or peptide nucleic acid building blocks which are linked via internucleotide bridges and which encompasses a region which is complementary, preferably completely complementary, to a target nucleic acid (target RNA or target DNA), with the dendrimer being bonded to an internucleotide bridge, a nucleic acid base or a sugar of the oligonucleotide, and the salts thereof. |
