发明名称 |
HYBRID COMPOSITIONS FOR INTRACELLULAR TARGETING |
摘要 |
Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which is capable of specific binding to Gb3; and the second domain comprising a moiety selected from the group consisting of drug moiety, a nucleic acid, a probe, a polypeptide, and a hook, with the proviso that the second domain is not a verotoxin or a fragment thereof. Methods of preparing and using the hybrid compounds are also provided. Also provided are nucleic acid molecules which encode hybrid molecule of the invention, recombinant vectors including a nucleic acid molecule of the invention in a form suitable for expression of the fusion protein in a host cell, and host cells including a recombinant vector of the invention. |
申请公布号 |
WO9822140(A2) |
申请公布日期 |
1998.05.28 |
申请号 |
WO1997IB01620 |
申请日期 |
1997.11.22 |
申请人 |
HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP;ARAB, SARA;LINGWOOD, CLIFFORD, A.;KHINE, AYE-AYE |
发明人 |
ARAB, SARA;LINGWOOD, CLIFFORD, A.;KHINE, AYE-AYE |
分类号 |
C12N15/09;A61K38/00;A61K47/48;A61K48/00;A61K51/00;C07K14/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12Q1/68;C12R1/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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