发明名称 |
PEPTIDOMIMETICS CONTAINING 6-PEPTIDYLAMINO-1-NAPHTHALENESULFONAMIDE MOIETIES |
摘要 |
Disclosed are compounds of formula (I) or the pharmaceutically acceptable nontoxic salts thereof wherein: R1 is benzyl group or a peptide of formula (a) wherein R3 and R4 independently represent free or protected amino acid side chains; R5 is hydroxy, alkoxy, benzoxy, an amino acid or a peptide residue; and R2 is an amino acid or a peptide residue, which compounds are inhibitors of activated protein C having high specificity for the enzyme. The present invention also provides compounds of formula (II) or the pharmaceutically acceptable salts thereof wherein: R3 and R4 independently represent free or protected amino acid side chains; R5 is hydroxy, alkoxy, benzoxy, an amino acid or a peptide residue; and R6 is 6-aminonaphthalenesulfonamide attached to the peptide group via the sulfonamide nitrogen atom or either a free or protected amino group attached to the peptide group via a terminal nitrogen atom.
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申请公布号 |
CA2272095(A1) |
申请公布日期 |
1998.05.28 |
申请号 |
CA19972272095 |
申请日期 |
1997.11.18 |
申请人 |
BUTENAS, SAULIUS;MANN, KENNETH G. |
发明人 |
BUTENAS, SAULIUS;MANN, KENNETH G. |
分类号 |
A61K38/00;A61P7/04;C07K5/00;C07K5/06;C07K5/068;C07K5/072;C07K5/083;C07K5/09;C07K5/093;C07K5/103;C07K5/11;C07K5/117;C07K7/00;C07K7/06;(IPC1-7):A61K38/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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