发明名称 |
Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
摘要 |
An improved process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane./!
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申请公布号 |
US5756728(A) |
申请公布日期 |
1998.05.26 |
申请号 |
US19960777072 |
申请日期 |
1996.12.30 |
申请人 |
JOHNSON MATTHEY PUBLIC LIMITED COMPANY |
发明人 |
XU, DAVID;KAPA, PRASAD;REPIC, OLJAN;BLACKLOCK, THOMAS J. |
分类号 |
C07C233/00;C07C233/36;C07C303/00;C07C311/18;C07D257/02;(IPC1-7):C07D259/00;A61K31/395 |
主分类号 |
C07C233/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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