发明名称 |
Peptides derived from endothelial cell growth factor |
摘要 |
Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa endothelial cell mitogen that has been purified to homogeneity from human platelets. It does not bind to heparin and does not stimulate the proliferation of fibroblasts, in contrast to other endothelial mitogens of the fibroblast growth factor (FGF) family. PD-ECGF appears to be the only endothelial cell growth factor in human platelets and recent data indicate that it has angiogenic activity in vitro, i.e., the ability to stimulate the formation of new blood vessels and chemotactic activity, in vitro. The present invention provides a homogeneous PD-ECGF in substantially greater yields than available in the past, the primary structure of PD-ECGF, antibodies against PD-ECGF, clones of its cDNA, and variants thereof. The invention also provides a therapeutic preparation of PD-ECGF.
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申请公布号 |
US5756686(A) |
申请公布日期 |
1998.05.26 |
申请号 |
US19910192757 |
申请日期 |
1991.11.15 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
HELDIN, CARL-HENRIK;MIYAZONO, KOHEI;WERNSTEDT, CHRISTER;HELLMAN, ULF;TAKAKU, FUMIMARO;ISHIKAWA, FUYUKI |
分类号 |
C07K14/475;C07K16/22;C12N15/18;(IPC1-7):C12N15/18 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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