发明名称 Stabilized potent GRF analogs
摘要 Novel GRF PEPTIDES having Thr, Val or Ile at position 2, having an amino acid selected from the group consisting of Ala, Val, Leu, Ile or Gly at position 15, and optionally substituted with Val or Ile at position 19 are described. Compositions and the method of stimulating the release of growth hormone utilizing GRF PEPTIDES having Thr, Val or Ile at position 2 and having an amino acid selected from the group consisting of Ala, Val, Leu, Ile or Gly at position 15 are also described. The GRF PEPTIDES of the present invention have enhanced stability in plasma.
申请公布号 US5756458(A) 申请公布日期 1998.05.26
申请号 US19950442029 申请日期 1995.05.16
申请人 PHARMACIA & UPJOHN COMPANY 发明人 KUBIAK, TERESA M.;FRIEDMAN, ALAN R.
分类号 A61K38/00;C07K14/60;(IPC1-7):A61K38/25 主分类号 A61K38/00
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