发明名称 |
Semi-synthetic taxanes with anti-tumoural activity |
摘要 |
The present invention relates to novel derivatives obtained by oxidation and the stereospecific reduction of 10-deacetylbaccatine III, and successive esterification with a variously substituted isoserine chain to prepare taxol analogues. The products of the invention have cytotoxic and anti-tumoural activities and, when suitably formulated, can be administered by injection and/or orally.
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申请公布号 |
US5756776(A) |
申请公布日期 |
1998.05.26 |
申请号 |
US19950505924 |
申请日期 |
1995.07.24 |
申请人 |
INDENA S.P.A. |
发明人 |
BOMBARDELLI, EZIO;GABETTA, BRUNO;DE BELLIS, PAOLO |
分类号 |
A61K31/00;A61K31/335;A61K31/337;A61P35/00;C07D305/06;C07D305/14;(IPC1-7):C07D305/14 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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