Process for enzymatic acylation of alcohols with alkoxyvinyl acetates by transesterification

摘要

Methods for the enzyme catalyzed acylation of primary and secondary alcohols using an enol ester as the acyl donor are described. The acylation occurs in organic media, and is enantioselective for racemic or prochiral alcohols. The reaction is irreversible, and produces unreactive by-products./!