发明名称 |
Hydroxamic acid-based bifunctional chelating compounds |
摘要 |
The present disclosure details the preparation of hydroxamic-acid based bifunctional chelators and their use in conjugating metal ions to proteins and nucleic acids for tumor or tissue imaging or therapy purposes. Some preferred aspects of the disclosure involve the preparation of trisuccin, chemical name N-[tris(2-N- benzyloxyaminocarbonylethyl)] methylsuccinamic acid, which is a hydroxamic acid/succinate based structure that is particularly useful for binding radionuclides such as 99mTc, 186Re and 67Cu.
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申请公布号 |
US5756825(A) |
申请公布日期 |
1998.05.26 |
申请号 |
US19930048869 |
申请日期 |
1993.04.16 |
申请人 |
SAFAVY, AHMAD;BUCHSBAUM, DONALD J.;KAZAELI, MOHAMMAD BAGHER |
发明人 |
SAFAVY, AHMAD;BUCHSBAUM, DONALD J.;KAZAELI, MOHAMMAD BAGHER |
分类号 |
A61K51/10;C07C259/06;C07K5/02;(IPC1-7):C07C229/00;C07C239/00 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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