发明名称 |
METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS |
摘要 |
The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound and a neurotrophic factor, such as nerve growth factor (NGF). The methods comprise treating nerve cells with the above compositions or compositions comprising the compound without a neurotrophic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.
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申请公布号 |
CA2270629(A1) |
申请公布日期 |
1998.05.22 |
申请号 |
CA19972270629 |
申请日期 |
1997.11.13 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
SU, MICHAEL;ZELLE, ROBERT E. |
分类号 |
C07D213/30;A61K31/4406;A61K31/4409;A61K31/4545;A61K31/4725;A61K38/18;A61K38/30;A61P25/28;A61P43/00;C07D401/12;(IPC1-7):A61K38/18;A61K45/06 |
主分类号 |
C07D213/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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