SYNTHESIS AND PURIFICATION OF HEPATITIS C VIRUS-LIKE PARTICLES
摘要
Production of enveloped RNA virus-like particles intracellularly in vitro in insect cells using a recombinant baculovirus vector containing a cDNA coding for viral structural proteins is disclosed. In vitro production and purification of hepatitis C virus (HCV)-like particles containing HCV core protein, E1 protein and E2 protein is disclosed. Production of antibodies in vivo to the purified HCV-like particles is disclosed.
申请公布号
WO9821338(A1)
申请公布日期
1998.05.22
申请号
WO1997US05096
申请日期
1997.03.25
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, RE;LIANG, T., JAKE;BAUMERT, THOMAS, F.