| 发明名称 |
2R,4S,R,R- AND 2S,4R,R,R-HYDROXYITRACONAZOLE |
| 摘要 |
A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl R,R-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and their use for the treatment of fungal infection are also disclosed.
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| 申请公布号 |
CA2269622(A1) |
申请公布日期 |
1998.05.22 |
| 申请号 |
CA19972269622 |
申请日期 |
1997.11.12 |
| 申请人 |
SEPRACOR INC. |
发明人 |
MCCULLOUGH, JOHN R.;HONG, YAPING;SENANAYAKE, CHRIS H.;KOCH, PATRICK;TANOURY, GERALD J. |
| 分类号 |
C07D405/14;A61K31/496;A61P31/10;C07D249/12;C07D405/06;C07D521/00;(IPC1-7):C07D405/14;A61K31/495 |
主分类号 |
C07D405/14 |
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