发明名称 |
COMPACT MEMBER COMPRISING A PLURALITY OF POROUS CELLULOSE MATRICES, (PCMS), METHOD OF MANUFACTURING AND USE THEREOF |
摘要 |
The invention relates to a compact member comprising a plurality of porous cellulose matrices (PCMs), and providing extended release of an active compound located in the pores of said PCMs together with a release-modifying agent. The friability of the compact member is less than 2.1%, and the disintegration time in vitro of said compact member is less than 240 minutes. The compact member is manufactured by exposing a plurality of PCMs to an active compound and a release-modifying agent, in optional sequence or mixture, for a time sufficient for said active compound and release-modifying agent to fill the pores in said PCMs to a preselected level. The PCMs are subsequently compacted to a desired shape. The invention further relates to use of the compact members for administration of a drug.
|
申请公布号 |
CA2271652(A1) |
申请公布日期 |
1998.05.22 |
申请号 |
CA19972271652 |
申请日期 |
1997.11.12 |
申请人 |
PHARMACIA & UPJOHN AB |
发明人 |
NYSTROEM, CHRISTER;GREN, TORKEL |
分类号 |
A61K9/14;A01N25/08;A01N25/34;A61K9/16;A61K9/20;A61K9/22;A61K47/38;C05G3/00;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|