发明名称 |
EX-CORPORE METHOD FOR TREATING HUMAN BLOOD CELLS |
摘要 |
This invention relates to an ex-corpore method of treating human blood cells incorporating tumour cells particularly in the frame of High-Dose Chemotherapy and/or Total Body Irradiation. According to the invention, a) carriers selective for specific tumour cells are conjugated to radionuclides which emit short range alpha particles with high linear energy transfer, forming a radioimmunoconjugate, b) a filtration/separation step is performed on the radioimmunoconjugate ensuring the removal of non-conjugated radionuclides, c) stem cells extracted from said blood and/or bone marrow, extracted from a patient for autologous transplant, are mixed ex-corpore with said conjugated radionuclides, d) after an incubation period a purging of the blood cells and/or bone marrow is performed.
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申请公布号 |
CA2270391(A1) |
申请公布日期 |
1998.05.22 |
申请号 |
CA19972270391 |
申请日期 |
1997.11.10 |
申请人 |
EUROPEAN ATOMIC ENERGY COMMUNITY (EURATOM) |
发明人 |
DEZEURE, FREDDY;VAN GEEL, JACQUES;KOCH, LOTHAR;VANSTRAELEN, DANNY;JANSSENS, WILLEM |
分类号 |
A61K51/00;A61K49/00;A61K51/10;A61K51/12;A61P35/00;(IPC1-7):A61K51/12 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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